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EMERGENT LIFE SCIENCES RESEARCH - Vol 3, Issue 1, Published on 30, June 2017

Pages: 38-47
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Formulation Development and In Vitro Evaluation of Propranolol Hydrochloride Extended Release Matrix Tablets

Author: V. Togaru, R. K. Venisetty, V. Bakshi, R. K. Jadi

Category: Research Article


The purpose of this investigation is to develop extended release matrix tablets of propranolol hydrochloride (PPH), which were designed to improve the patient compliance and prolong the drug release after oral administration. Different viscosity grades of hydroxypropyl methylcellulose (HPMC) polymers such as HPMC K4 M, HPMC K15 M and HPMC K100 M were used. The prepared formulations were characterized and all formulations exhibited satisfactory physical parameters such as thickness (mm), weight variation (mg), friability (%) and hardness (kg/cm2). After evaluation of physical properties, the in vitro release study was performed in 0.1 N Hydrochloric Acid (HCl), pH 1.2 for 2 hours followed by release in phosphate buffer pH 6.8 up to 12 hours. The effects of polymer concentration and polymer blend concentration were studied. Among all the formulations, formulation F3 which contains 40% HPMC K4M followed zero order kinetics via, swelling, diffusion and erosion. This study gives the preliminary idea about the development of extended release drug delivery systems of PPH. The in-vitro drug release exponent of the peppas equation suggests the drug release mechanism was super case II transport mechanism. Based on compatibility studies such as differential scanning calorimetry (DSC) and fourier transform infrared spectrophotometry (FT-IR), there was no interaction between the drug and excipients.

Keywords: differential scanning calorimetry, extended release tablets, fourier transforms infrared spectrophotometry, Propranolol, in vitro drug release